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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Captopril

4

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1
Last update : 07/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Angiotensin converting enzyme inhibitor toxicity causing interstitial pneumonitis and cholestatic hepatitis.
European journal of internal medicine 2006 Jan;17;73 2006 Jan
Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.
Pediatric cardiology 2005;26;690-3 2005
Captopril, an angiotensin-converting enzyme inhibitor, induced pulmonary infiltration with eosinophilia.
Internal medicine (Tokyo, Japan) 1996 Feb;35;142-5 1996 Feb
Captopril-induced hypersensitivity lung disease. An immune-complex-mediated phenomenon.
Chest 1989 Mar;95;685-7 1989 Mar

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