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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Glitazones

3

XII.a Left or biventricular dysfunction/failure

2
Last update : 17/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Thiazolinediones and heart failure: the potential to precipitate irreversible cardiac dysfunction.
International journal of cardiology 2008 Jan 11;123;e35-7 2008 Jan 11
Thiazolidinedione-associated congestive heart failure and pulmonary edema.
Mayo Clinic proceedings 2003 Sep;78;1088-91 2003 Sep

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