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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chemicals

5

IV.q Reactive airway dysfunction syndrome (RADS)

3
Last update : 28/01/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aniline - Aminophenols
1
Caustic chemicals
3
Diacetyl (2,3-butanedione) flavoring agent
3
Gases
5
Hydrocarbons (petrochemicals: petroleum, petrolatum, paraffin, vaseline, naphta, jet fuel (kerosene), Diesel, gasoil), ointments, salad oil, variegated oils, butter). Aspirated
5
Laundry detergent pods
3
Nail polish remover
1
Nitric acid fumes
1
Nitrites - Nitrates (oral - inhaled ('Poppers'))
3
Nitrobenzene
3
Potassium permanganate
1
Trichloroethylene
1

Publications

Chemical Pneumonitis and Reactive Airways Dysfunction Syndrome After Fumigation Exposure to Dimethanol and Glutaraldehyde: A Silent Menace Unmasked.
Cureus 2023 Aug;15;e42939 2023 Aug
A 27-Year-Old Man With Persistent Breathlessness After an Inhalational Injury.
Chest 2021 Apr;159;e197-e201 2021 Apr
Chronic pulmonary dysfunction following acute inhalation of butyl acrylate.
The West Virginia medical journal 2012;108;28-32 2012
Chemical pneumonitis and subsequent reactive airways dysfunction syndrome after a single exposure to a household product: a case report.
Journal of medical case reports 2009 Nov 09;3;112 2009 Nov 09
Severe airway disease due to inhalation of fumes from cleansing agents.
Chest 1976 Mar;69;372-6 1976 Mar

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