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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ipilimumab

4

II.b ARDS - Acute lung injury

1
Last update : 19/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
CTLA4 blocking immunotherapy
3
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5
Tremelimumab
1

Publications

Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy.
British journal of cancer 2016 May 10;114;1084-9 2016 May 10
Checkpoint blocking antibodies in cancer immunotherapy.
FEBS letters 2014 Jan 21;588;368-76 2014 Jan 21
The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network.
PloS one 2013;8;e53745 2013

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