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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Highly active antiretroviral therapy - HAART

3

X.i The immune reconstitution syndrome (IRCS)

3
Last update : 30/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abacavir
2
Dolutegravir
1
Sofosbuvir
1

Publications

Large liquefaction of lymph nodes during tuberculosis-associated immune reconstitution inflammatory syndrome in an HIV-infected woman.
BMJ case reports 2012 Sep 24;2012; 2012 Sep 24
Acute microbiologically negative hypoxic interstitial pneumonia on HAART: Immune Reconstitution Inflammatory Syndrome unmasking Pneumocystis jiroveci infection with an atypical presentation.
Journal of medicine and life 2012 Jun 12;5;189-91 2012 Jun 12
Pulmonary manifestations of the immune reconstitution inflammatory syndrome.
Current opinion in pulmonary medicine 2011 May;17;180-8 2011 May
Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy.
Medicine 2002 May;81;213-27 2002 May
Reconstitution of immune responses to tuberculosis in patients with HIV infection who receive antiretroviral therapy.
Chest 2002 Aug;122;597-602 2002 Aug

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