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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trimethoprim sulfamethoxazole (TMP-SMX)

3

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1
Last update : 12/02/2022
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Sulfadoxine
1
Sulfamethoxypyridazine
1
Sulfamides - Sulfonamides
3
Sulfasalazine
3

Publications

The use of bilateral orthotopic lung transplantation in the management of acute severe drug-induced interstitial lung disease: A case report.
JHLT open 2024 Aug;5;100108 2024 Aug
Trimethoprim-sulfamethoxazole-induced lung injury: a case report.
Translational pediatrics 2023 Nov 28;12;2062-2073 2023 Nov 28
ARDS With Pneumothorax in a Young Adult.
Chest 2022 Feb;161;e111-e116 2022 Feb

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