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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trimethoprim sulfamethoxazole (TMP-SMX)

3

XV.f Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

2
Last update : 06/04/2021
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Sulfadoxine
1
Sulfamethoxypyridazine
1
Sulfamides - Sulfonamides
3
Sulfasalazine
3

Publications

Trimethoprim-Sulfamethoxazole-associated Fulminant Respiratory Failure in Children and Young Adults.
American journal of respiratory and critical care medicine 2021 Apr 01;203;918-921 2021 Apr 01
Sulfa-induced acute eosinophilic pneumonia.
Respiratory medicine case reports 2021;34;101496 2021

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