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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trimethoprim sulfamethoxazole (TMP-SMX)

3

XIV.a Methemoglobinemia

1
Last update : 21/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Sulfadoxine
1
Sulfamethoxypyridazine
1
Sulfamides - Sulfonamides
3
Sulfasalazine
3

Publications

Methemoglobinemia induced by trimethoprim-sulfamethoxazole in a patient with systemic lupus erythematosus.
Internal medicine (Tokyo, Japan) 2013;52;1741-3 2013
Use of telemedicine for the identification and treatment of sulfamethoxazole-induced methaemoglobinemia.
Journal of telemedicine and telecare 2012 Sep;18;362-4 2012 Sep
Methaemoglobinaemia secondary to treatment with trimethoprim and sulphamethoxazole associated with inhaled nitric oxide.
Acta paediatrica (Oslo, Norway : 1992) 1999 Aug;88;915-6 1999 Aug

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