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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trimethoprim sulfamethoxazole (TMP-SMX)

3

I.b Pneumonitis (ILD)

1
Last update : 23/03/2024
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Sulfadoxine
1
Sulfamethoxypyridazine
1
Sulfamides - Sulfonamides
3
Sulfasalazine
3

Publications

Lung toxicity related to trimethoprim/sulfamethoxazole: pharmacovigilance data review.
The Journal of antimicrobial chemotherapy 2025 Apr 02;80;1148-1152 2025 Apr 02
Interstitial lung disease during trimethoprim/sulfamethoxazole administration.
Acta medica Okayama 2010 Jun;64;181-7 2010 Jun
Drug-induced pneumonitis caused by sulfamethoxazole, trimethoprim during treatment of Pneumocystis carinii pneumonia in a patient with refractory ulcerative colitis.
Journal of gastroenterology 1998 Aug;33;578-81 1998 Aug

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