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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trimethoprim sulfamethoxazole (TMP-SMX)

3

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

1
Last update : 15/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Sulfadoxine
1
Sulfamethoxypyridazine
1
Sulfamides - Sulfonamides
3
Sulfasalazine
3

Publications

Six-hour trimethoprim-sulfamethoxazole-graded challenge in HIV-infected patients.
The Journal of allergy and clinical immunology 1998 Dec;102;1033-6 1998 Dec
Drugs as allergens: detection and combining site specificities of IgE antibodies to sulfamethoxazole.
Molecular immunology 1988 Dec;25;1347-54 1988 Dec

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