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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trimethoprim sulfamethoxazole (TMP-SMX)

3

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1
Last update : 15/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Sulfadoxine
1
Sulfamethoxypyridazine
1
Sulfamides - Sulfonamides
3
Sulfasalazine
3

Publications

Anaphylactoid Reaction from Trimethoprim-Sulfamethoxazole with Subsequent T-wave Inversions in a Young Patient with Dermatomyositis.
The Journal of clinical and aesthetic dermatology 2019 Nov;12;20-22 2019 Nov
Anaphylactic drug reaction to celecoxib and sulfamethoxazole: cross reactivity or coincidence?
Allergy 2003 Oct;58;1072 2003 Oct
Trimethoprim-sulfamethoxazole anaphylactoid reactions in patients with AIDS: case reports and literature review.
Pharmacotherapy 1990;10;413-6 1990
Severe hypersensitivity reaction upon rechallenge with trimethoprim-sulfamethoxazole in a patient with AIDS.
Drug intelligence & clinical pharmacy 1988 Jan;22;43-5 1988 Jan

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