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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trimethoprim sulfamethoxazole (TMP-SMX)

3

II.b ARDS - Acute lung injury

1
Last update : 30/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Sulfadoxine
1
Sulfamethoxypyridazine
1
Sulfamides - Sulfonamides
3
Sulfasalazine
3

Publications

Lung toxicity related to trimethoprim/sulfamethoxazole: pharmacovigilance data review.
The Journal of antimicrobial chemotherapy 2025 Apr 02;80;1148-1152 2025 Apr 02
The use of bilateral orthotopic lung transplantation in the management of acute severe drug-induced interstitial lung disease: A case report.
JHLT open 2024 Aug;5;100108 2024 Aug
Trimethoprim-sulfamethoxazole-induced lung injury: a case report.
Translational pediatrics 2023 Nov 28;12;2062-2073 2023 Nov 28
Suspected Case of Drug-Induced Acute Respiratory Distress Syndrome following Trimethoprim-Sulfamethoxazole Treatment.
Journal of pediatric intensive care 2022 Mar;11;67-71 2022 Mar
ARDS With Pneumothorax in a Young Adult.
Chest 2022 Feb;161;e111-e116 2022 Feb
Trimethoprim-Sulfamethoxazole-associated Fulminant Respiratory Failure in Children and Young Adults.
American journal of respiratory and critical care medicine 2021 Apr 01;203;918-921 2021 Apr 01
Severe Acute Respiratory Failure in Healthy Adolescents Exposed to Trimethoprim-Sulfamethoxazole.
Pediatrics 2019 Jun;143; 2019 Jun
Severe hypersensitivity reaction upon rechallenge with trimethoprim-sulfamethoxazole in a patient with AIDS.
Drug intelligence & clinical pharmacy 1988 Jan;22;43-5 1988 Jan
Pulmonary infiltrates and hypoxemia in patients with the acquired immunodeficiency syndrome re-exposed to trimethoprim-sulfamethoxazole.
The American review of respiratory disease 1987 Oct;136;1003-4 1987 Oct

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