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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trimethoprim sulfamethoxazole (TMP-SMX)

3

II.a Pulmonary edema, noncardiogenic (NCPE)

1
Last update : 30/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Sulfadoxine
1
Sulfamethoxypyridazine
1
Sulfamides - Sulfonamides
3
Sulfasalazine
3

Publications

Trimethoprim-sulfamethoxazole reaction simulating Pneumocystis carinii pneumonia.
AIDS (London, England) 1991 Aug;5;1029 1991 Aug
Reaction after re-exposure to trimethoprim-sulfamethoxazole.
Chest 1989 Apr;95;937-8 1989 Apr
Pulmonary infiltrates and hypoxemia in patients with the acquired immunodeficiency syndrome re-exposed to trimethoprim-sulfamethoxazole.
The American review of respiratory disease 1987 Oct;136;1003-4 1987 Oct

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