Pneumotox » Drug » Timolol » I.d - Organizing pneumonia pattern (an area or areas of consolidation on imaging)

Timolol

See Case Records of the Massachusetts General Hospital - Case 17-1991. N Engl J Med 1991; 324: 1195-1206 (PMID 2011164)

Last update : 29/10/2012

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment