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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Timolol

2

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 07/10/2014
 
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Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Beta-blockers
5

Publications

Avoiding unsuspected respiratory side-effects of topical timolol with cardioselective or sympathomimetic agents.
Lancet (London, England) 1995 Jun 24;345;1604-6 1995 Jun 24
Unsuspected bronchospasm in association with topical timolol--a common problem in elderly people: can we easily identify those affected and do cardioselective agents lead to improvement?
Age and ageing 1994 Jan;23;17-21 1994 Jan
[Severe bronchial spasm crises induced by topical administration of eyedrops with timolol base, a non-selective beta blocking agent].
Recenti progressi in medicina 1991;82;402-4 1991
Respiratory arrest following first dose of timolol ophthalmic solution.
Chest 1983 Nov;84;640-1 1983 Nov
Timolol eyedrop-induced severe bronchospasm.
Acta medica Scandinavica 1982;211;505-6 1982

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