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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Acetylcysteine (N-acetylcysteine)

2

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

2
Last update : 12/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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Pills - Tablets
5

Publications

Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning.
Journal of medical toxicology : official journal of the American College of Medical Toxicology 2018 Jun;14;120-127 2018 Jun
Adverse reactions associated with acetylcysteine.
Clinical toxicology (Philadelphia, Pa.) 2009 Feb;47;81-8 2009 Feb
[Side-effects of N-acetylcysteine treatment in patients with paracetamol poisoning].
Ugeskrift for laeger 1999 May 03;161;2669-72 1999 May 03
Adverse reactions to acetylcysteine and effects of overdose.
British medical journal (Clinical research ed.) 1984 Jul 28;289;217-9 1984 Jul 28

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