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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Status post-hematopoietic stem cell (HSCT) or bone marrow transplantation (BMT)

5

XV.bv Path: Pulmonary cytolytic thrombi

1
Last update : 21/09/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary cytolytic thrombi after allogeneic hematopoietic cell transplantation: a further histologic description.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2005 Jun;11;484-5 2005 Jun

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