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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Status post-hematopoietic stem cell (HSCT) or bone marrow transplantation (BMT)

5

VI.b Pulmonary arterial hypertension

1
Last update : 11/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary arterial hypertension in pediatric patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2013 Feb;19;202-7 2013 Feb
Pulmonary hypertension associated with bone marrow transplantation.
Journal of cardiology cases 2010 Aug;2;e23-e27 2010 Aug
Severe pulmonary hypertension: a frequent complication of stem cell transplantation for malignant infantile osteopetrosis.
British journal of haematology 2004 Jan;124;63-71 2004 Jan

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