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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Status post-hematopoietic stem cell (HSCT) or bone marrow transplantation (BMT)

5

IV.c Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)

5
Last update : 06/05/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Late-onset noninfectious pulmonary complications in adult allogeneic hematopoietic cell transplant recipients.
Transplantation 2011 Apr 15;91;798-803 2011 Apr 15
Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantation.
Bone marrow transplantation 2001 Sep;28;425-34 2001 Sep
Pulmonary complications after bone marrow transplantation: high-resolution CT and pathologic findings.
Radiographics : a review publication of the Radiological Society of North America, Inc 1997;17;1359-71 1997
Diagnosis of bronchiolitis obliterans in heart-lung transplantation patients: importance of bronchial dilatation on CT.
AJR. American journal of roentgenology 1992 Sep;159;463-7 1992 Sep

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