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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Status post-hematopoietic stem cell (HSCT) or bone marrow transplantation (BMT)

5

X.c Capillary leak syndrome (CLS)

2
Last update : 28/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Engraftment syndrome following hematopoietic stem cell transplantation.
Bone marrow transplantation 2001 May;27;893-8 2001 May

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