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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Status post-hematopoietic stem cell (HSCT) or bone marrow transplantation (BMT)

5

II.e Transfusion-related acute lung injury (TRALI) (May cause ARDS)

2
Last update : 18/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Transfusion-related acute lung injury.
Blood reviews 2006 May;20;139-59 2006 May
Transfusion-related acute lung injury (TRALI) following allogeneic stem cell transplant for acute myeloid leukemia.
American journal of hematology 2004 Jan;75;48-51 2004 Jan
TRALI after the infusion of marrow cells in a patient with acute lymphoblastic leukemia.
Transfusion 2003 Nov;43;1553-7 2003 Nov

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