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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ecstasy (MDMA)

4

XII.b Valvular heart disease and/or dysfunction

1
Last update : 30/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Amphetamine (and -derivatives)
3

Publications

Valvular heart disease in a patient taking 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy').
British journal of clinical pharmacology 2012 Sep;74;547-8 2012 Sep
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
Molecular pharmacology 2003 Jun;63;1223-9 2003 Jun

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