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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Busulfan

5

XV.f Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

2
Last update : 02/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Busulfan + Melphalan regimen
1

Publications

Drug-induced lung disease: a pragmatic classification incorporating HRCT appearances.
Seminars in respiratory and critical care medicine 2003 Aug;24;445-54 2003 Aug
Pulmonary lesions associated with busulfan therapy of chronic myelogenous leukemia.
Cancer 1971 May;27;1074-80 1971 May
Interstitial pulmonary fibrosis, atypical epithelial changes and bronchiolar cell carcinoma following busulfan therapy.
Cancer 1968 Nov;22;1027-32 1968 Nov

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