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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Phentermine

3

XII.b Valvular heart disease and/or dysfunction

3
Last update : 10/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Valvular heart disease with the use of fenfluramine-phentermine.
Texas Heart Institute journal 2011;38;581-3 2011
Aortic and mitral fenfluramine-phentermine valvulopathy in 64 patients treated with anorectic agents.
Archives of pathology & laboratory medicine 2001 Dec;125;1555-61 2001 Dec
Aminorex to fen/phen: an epidemic foretold.
Circulation 1999 Jan 5-12;99;156-61 1999 Jan 5-12
Valvular heart disease associated with fenfluramine-phentermine.
The New England journal of medicine 1997 Dec 11;337;1772; author reply 1775 1997 Dec 11
Further cases of valvular heart disease associated with fenfluramine-phentermine.
The New England journal of medicine 1997 Aug 28;337;635 1997 Aug 28
Valvular heart disease associated with fenfluramine-phentermine.
The New England journal of medicine 1997 Aug 28;337;581-8 1997 Aug 28

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