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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Phentermine

3

VI.b Pulmonary arterial hypertension

1
Last update : 10/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

RE: Pulmonary hypertension associated with use of phentermine?
Yonsei medical journal 2011 Sep;52;869-70 2011 Sep
Pulmonary hypertension associated with use of phentermine.
Yonsei medical journal 2010 Nov;51;971-3 2010 Nov
Autopsy findings of heart and lungs in a patient with primary pulmonary hypertension associated with use of fenfluramine and phentermine.
Chest 2002 Feb;121;649-52 2002 Feb
Aminorex to fen/phen: an epidemic foretold.
Circulation 1999 Jan 5-12;99;156-61 1999 Jan 5-12
Fatal pulmonary hypertension associated with short-term use of fenfluramine and phentermine.
The New England journal of medicine 1997 Aug 28;337;602-6 1997 Aug 28

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