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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Sitagliptin
1
IV.d
Cough (lone)
1
No statistical evidence found, however (PMID 31980869)
Last update :
02/02/2020
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Angiotensin converting enzyme inhibitors (ACEI)
Gliptins
Linagliptin
Saxagliptin
Vildagliptin
Publications
Falsely Accused? Insufficient Evidence to Conclude that Sitagliptin is a Cause of Chronic Cough.
Rhinorrhea, cough and fatigue in patients taking sitagliptin.