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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy to the chest

5

I.v Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence

3

Correlate with involved field and radiation dose

Last update : 04/05/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (early effects)
5
Radiation therapy (endobronchial brachytherapy)
2
Radiation therapy (medium term & late effects)
5
Radiation therapy to the breast
4
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
2
Radiation therapy, mantle-field-
5
Radiation therapy, stereotactic (SBRT)
5
Radioactive seeds
2

Publications

Correlation of pulmonary function abnormalities with dose volume histograms in children treated with lung irradiation.
Pediatric pulmonology 2015 Jun;50;596-603 2015 Jun
Pulmonary outcomes in patients with Hodgkin lymphoma treated with involved field radiation.
Pediatric blood & cancer 2014 Jul;61;1277-81 2014 Jul
Pulmonary function after whole lung irradiation in pediatric patients with solid malignancies.
Cancer 2012 Mar 01;118;1450-6 2012 Mar 01
The pulmonary status of patients with limited-stage small cell lung cancer 15 years after treatment with chemotherapy and chest irradiation.
Chest 2005 Nov;128;3261-8 2005 Nov

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