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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy to the chest

5

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2

May progress to full-blown ARDS

Last update : 04/05/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (early effects)
5
Radiation therapy (endobronchial brachytherapy)
2
Radiation therapy (medium term & late effects)
5
Radiation therapy to the breast
4
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
2
Radiation therapy, mantle-field-
5
Radiation therapy, stereotactic (SBRT)
5
Radioactive seeds
2

Publications

[Predictive factors for acute radiation pneumonitis].
Revue de pneumologie clinique 2009 Jun;65;177-86 2009 Jun
Radiotherapy-induced lung toxicity: risk factors and prevention strategies.
Anticancer research 2003;23;4991-8 2003
Hyperacute radiation pneumonitis.
Chest 1975 May;67;613-5 1975 May

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