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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy (medium term & late effects)

5

XII.g Coronary artery disease (acute) - Myocardial ischemia/infarction

2

Review at 24092234

Last update : 03/11/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (early effects)
5
Radiation therapy to the breast
4
Radiation therapy to the chest
5
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
2
Radiation therapy, mantle-field-
5
Radiation therapy, stereotactic (SBRT)
5

Publications

How to prevent and manage radiation-induced coronary artery disease.
Heart (British Cardiac Society) 2018 Oct;104;1647-1653 2018 Oct
Dosimetric Correlate of Cardiac-Specific Survival Among Patients Undergoing Coronary Artery Stenting After Thoracic Radiotherapy for Cancer.
American journal of clinical oncology 2017 Apr;40;133-139 2017 Apr
Case records of the Massachusetts General Hospital. Case 24-2010. A 56-year-old woman with a history of Hodgkin's lymphoma and sudden onset of dyspnea and shock.
The New England journal of medicine 2010 Aug 12;363;664-75 2010 Aug 12
10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat model.
International journal of radiation biology 2009 Dec;85;1089-100 2009 Dec

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