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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy (medium term & late effects)

5

XII.f Cardiomyopathy (acute, subacute, chronic)

3

Review at 24092234

Last update : 03/11/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (early effects)
5
Radiation therapy to the breast
4
Radiation therapy to the chest
5
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
2
Radiation therapy, mantle-field-
5
Radiation therapy, stereotactic (SBRT)
5

Publications

Treatment-related cardiotoxicity in survivors of childhood cancer.
Nature reviews. Clinical oncology 2013 Dec;10;697-710 2013 Dec
Pathology of radiation-induced heart disease: a surgical and autopsy study of 27 cases.
Human pathology 1996 Aug;27;766-73 1996 Aug
Radiation therapy-induced cardiac injury.
American heart journal 1995 Jun;129;1193-6 1995 Jun

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