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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy (medium term & late effects)

5

IV.h Large airway necrosis

2
Last update : 29/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (early effects)
5
Radiation therapy to the breast
4
Radiation therapy to the chest
5
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
2
Radiation therapy, mantle-field-
5
Radiation therapy, stereotactic (SBRT)
5

Publications

Bronchoscopic Manifestations of Airway Toxicity After Radiotherapy.
Clinical lung cancer 2018 Nov;19;e875-e878 2018 Nov
Radiation-associated airway necrosis.
Ochsner journal 2013;13;273-5 2013
Posttreatment CT and MR imaging in head and neck cancer: what the radiologist needs to know.
Radiographics : a review publication of the Radiological Society of North America, Inc 2012;32;1261-82; discussion 1282-4 2012
Necrosis of the bronchus. Role of radiation.
Chest 1995 Nov;108;1462-6 1995 Nov

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