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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Radiation therapy (medium term & late effects)
5
IV.h
Large airway necrosis
2
Last update :
29/04/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (early effects)
Radiation therapy to the breast
Radiation therapy to the chest
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
Radiation therapy, mantle-field-
Radiation therapy, stereotactic (SBRT)
Publications
Bronchoscopic Manifestations of Airway Toxicity After Radiotherapy.
Radiation-associated airway necrosis.
Posttreatment CT and MR imaging in head and neck cancer: what the radiologist needs to know.
Necrosis of the bronchus. Role of radiation.
