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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy (medium term & late effects)

5

V.h Chylothorax

2
Last update : 15/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (early effects)
5
Radiation therapy to the breast
4
Radiation therapy to the chest
5
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
2
Radiation therapy, mantle-field-
5
Radiation therapy, stereotactic (SBRT)
5

Publications

Etiology of chylothorax in 203 patients.
Mayo Clinic proceedings 2005 Jul;80;867-70 2005 Jul
Chylothorax occurring 23 years post-irradiation: literature review and management strategies.
Respirology (Carlton, Vic.) 2000 Sep;5;301-3 2000 Sep
Chylothorax from radiation-induced mediastinal fibrosis.
Australian and New Zealand journal of medicine 1998 Oct;28;667-8 1998 Oct
Chylothorax: the result of previous radiation therapy?
The Journal of the American Osteopathic Association 1997 Mar;97;164-6 1997 Mar
Delayed chylothorax after irradiation.
The Annals of thoracic surgery 1996 Jan;61;277 1996 Jan
Chylothorax and pleural effusion as late complications of thoracic irradiation.
Chest 1995 Sep;108;886-7 1995 Sep
Thoracoscopic ligation of a thoracic duct leakage.
Chest 1994 Oct;106;1233-4 1994 Oct
Chylothorax after mantle field irradiation for Hodgkin's disease.
Respiration; international review of thoracic diseases 1985;48;188-9 1985

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