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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Acitretin

1

X.c Capillary leak syndrome (CLS)

1
Last update : 14/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Acitretin induces capillary leak syndrome in a patient with pustular psoriasis.
Journal of the American Academy of Dermatology 2007 Feb;56;339-42 2007 Feb
Capillary leak syndrome induced by acitretin.
The British journal of dermatology 2004 Jan;150;150-2 2004 Jan

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