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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sorafenib

2

XII.a Left or biventricular dysfunction/failure

2
Last update : 22/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Sunitinib
2

Publications

Severe Reversible Heart Failure Enhanced by Sorafenib Treatment for Hepatocellular Carcinoma.
Cureus 2025 Jan;17;e76993 2025 Jan
Efficacy of sorafenib and impact on cardiac function in patients with thyroid cancer: a retrospective analysis.
Journal of endocrinological investigation 2014 Nov;37;1099-108 2014 Nov
Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008 Nov 10;26;5204-12 2008 Nov 10

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