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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Crizotinib

4

XV.f Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

1
Last update : 06/08/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Alk inhibitors
3

Publications

Fatal interstitial lung disease associated with Crizotinib pathologically confirmed by percutaneous lung biopsy in a patient with ROS1-rearranged advanced non-small-cell lung cancer: a case report.
BMC pulmonary medicine 2018 Jul 20;18;121 2018 Jul 20
Severe acute interstitial lung disease after crizotinib therapy in a patient with EML4-ALK-positive non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013 Jan 01;31;e15-7 2013 Jan 01

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