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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Paraquat

5

I.l Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

2
Last update : 13/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Glyphosate
2

Publications

Prospective evaluation of drug-induced lung toxicity with high-resolution CT and transbronchial biopsy.
La Radiologia medica 2011 Mar;116;246-63 2011 Mar
Sequential radiologic and functional pulmonary changes in patients with paraquat intoxication.
International journal of occupational and environmental health 2006;12;203-8 2006

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