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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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FOLFOX chemotherapy regimen

3

I.bb Fatal pulmonary fibrosis

1
Last update : 27/03/2025
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Fluorouracil (5-FU)
3
Oxaliplatin-based regimens
4

Publications

Oxaliplatin-Induced Pulmonary Fibrosis: A Rare but Fatal Reality.
Cureus 2023 Dec;15;e51411 2023 Dec

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