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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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FOLFOX chemotherapy regimen

3

II.b ARDS - Acute lung injury

2
Last update : 04/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Fluorouracil (5-FU)
3
Oxaliplatin-based regimens
4

Publications

Organizing pneumonia with fatal outcome after adjuvant chemotherapy with FOLFOX.
Archivos de bronconeumologia 2015 Nov;51;610 2015 Nov
Hemoptysis and acute respiratory syndrome (ARDS) as delayed-type hypersensitivity after FOLFOX4 plus bevacizumab treatment.
International surgery 2013;98;445-9 2013
Drug-associated acute lung injury: a population-based cohort study.
Chest 2012 Oct;142;845-850 2012 Oct
Interstitial lung disease in a patient treated with oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) for metastatic colorectal cancer.
Radiology and oncology 2012 Dec;46;360-2 2012 Dec
Oxaliplatin-induced lung toxicity. Case report and review of the literature.
Current drug safety 2012 Apr;7;179-82 2012 Apr

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