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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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MTOR inhibitors

5

VIII.a Angioedema (may cause UAO, asphyxia and death)

2
Last update : 06/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Everolimus
5
Ridaforolimus
2
Sirolimus
4
Temsirolimus
2
Zotarolimus
1

Publications

Increased incidence of angioedema with ACE inhibitors in combination with mTOR inhibitors in kidney transplant recipients.
Clinical journal of the American Society of Nephrology : CJASN 2010 Apr;5;703-8 2010 Apr
Lingual angioedema associated with everolimus.
Acta oncologica (Stockholm, Sweden) 2010;49;107-9 2010
Immunosuppressive therapy with everolimus can be associated with potentially life-threatening lingual angioedema.
Transplantation 2005 Apr 27;79;981-3 2005 Apr 27

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