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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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MTOR inhibitors

5

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1
Last update : 28/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Everolimus
5
Ridaforolimus
2
Sirolimus
4
Temsirolimus
2
Zotarolimus
1

Publications

Histological spectrum of pulmonary manifestations in kidney transplant recipients on sirolimus inclusive immunosuppressive regimens.
Diagnostic pathology 2012 Mar 14;7;25 2012 Mar 14
An unusual presentation of sirolimus associated cough in a renal transplant recipient.
Transplantation proceedings 2007 Dec;39;3463-4 2007 Dec
[Sirolimus-associated interstitial pneumonitis in a renal transplant patient].
La Revue de medecine interne 2006 Mar;27;248-52 2006 Mar

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