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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bromocriptine

3

XII.b Valvular heart disease and/or dysfunction

2
Last update : 09/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Ergots, ergot alkaloids, ergolines
4

Publications

Cardiac valve disease and low-dose dopamine agonist therapy: an artefact of reporting bias?
Clinical endocrinology 2011 May;74;608-10 2011 May
Cardiac and noncardiac fibrotic reactions caused by ergot-and nonergot-derived dopamine agonists.
Movement disorders : official journal of the Movement Disorder Society 2009 Jan 15;24;129-33 2009 Jan 15
Valvular heart disease in Parkinson's disease treated with ergot derivative dopamine agonists.
Movement disorders : official journal of the Movement Disorder Society 2006 Aug;21;1261-4 2006 Aug
Fibrotic valvular heart disease subsequent to bromocriptine treatment.
Cardiology in review 2002;10;334-6 2002

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