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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Silicone, fluid

5

XV.bn Path: Silicone droplets/vacuoles in lung tissue, pulmonary vasculature, or lymph nodes

2
Last update : 07/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Breast implants - Augmentation mammaplasty (w/wo evidence for leakage/rupture)
4

Publications

Pulmonary Empty Spaces: Silicone Embolism-A Decade of Increased Incidence and Its Histological Diagnosis.
Case reports in pathology 2016;2016;3741291 2016
Respiratory Disease following Illicit Injection of Silicone: A Case Report.
Case reports in medicine 2013;2013;743842 2013
Detection of silicone in lung tissue.
Archives of pathology & laboratory medicine 2012 Oct;136;1179-80; author reply 1180 2012 Oct
Pneumonitis caused by silicone gel following breast implant rupture.
Irish journal of medical science 2010 Mar;179;141-5 2010 Mar
Case report and literature review: acute pneumonitis and alveolar hemorrhage after subcutaneous injection of liquid silicone.
Annals of clinical and laboratory science 2008;38;380-5 2008
Massive systemic silicone embolism: a case report and review of literature.
The American journal of forensic medicine and pathology 2006 Jun;27;97-102 2006 Jun
Silicone pneumonitis after a cosmetic augmentation procedure.
The New England journal of medicine 2006 Jan 12;354;211-2 2006 Jan 12
Silicone embolism syndrome: a case report, review of the literature, and comparison with fat embolism syndrome.
Chest 2005 Jun;127;2276-81 2005 Jun
A case of acute pneumonitis induced by injection of silicone for colpoplasty.
Respiration; international review of thoracic diseases 2003;70;104-6 2003
Clinicopathologic review of pulmonary silicone embolism with special emphasis on the resultant histologic diversity in the lung--a review of five cases.
Yonsei medical journal 2002 Apr;43;152-9 2002 Apr
Acute pneumopathy in a nonsurgical transsexual.
Chest 1998 Apr;113;1127-9 1998 Apr
Acute pneumonitis after subcutaneous injections of silicone in transsexual men.
The New England journal of medicine 1983 Mar 31;308;764-7 1983 Mar 31
Injectable fluid silicone therapy. Human morbidity and mortality.
JAMA 1975 Oct 20;234;308-9 1975 Oct 20

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