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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Silicone, fluid

5

XIX.l BAL: Silicone globules in macrophages

1
Last update : 22/08/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Breast implants - Augmentation mammaplasty (w/wo evidence for leakage/rupture)
4

Publications

[Acute pneumonitis and adult respiratory distress syndrome after subcutaneous injection of liquid silicone].
Archivos de bronconeumologia 2005 Dec;41;702-3 2005 Dec
A case of acute pneumonitis induced by injection of silicone for colpoplasty.
Respiration; international review of thoracic diseases 2003;70;104-6 2003

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