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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Silicone, fluid

5

X.u Multiple organ dysfunction/failure (MODS/MOF)

1
Last update : 18/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Breast implants - Augmentation mammaplasty (w/wo evidence for leakage/rupture)
4

Publications

A 20-year-old woman with rapidly progressive dyspnea and diffuse pulmonary infiltrates.
Respiratory medicine case reports 2012;5;34-6 2012
Subcutaneous silicone injection leading to multi-system organ failure.
Clinical toxicology (Philadelphia, Pa.) 2008 Nov;46;834-7 2008 Nov

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