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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Silicone, fluid

5

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

2
Last update : 13/09/2012
 
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Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
More detailed checklist
See also under
Breast implants - Augmentation mammaplasty (w/wo evidence for leakage/rupture)
4

Publications

[Acute Respiratory Failure after Silicone Injection].
Pneumologie (Stuttgart, Germany) 2019 Oct;73;582-585 2019 Oct
Silicone pneumonitis, diffuse alveolar hemorrhage and acute respiratory distress syndrome from gluteal silicone injections.
The American journal of emergency medicine 2018 Dec;36;2340.e3-2340.e4 2018 Dec
Extracorporeal membrane oxygenation for diffuse alveolar hemorrhage and severe hypoxemic respiratory failure from silicone embolism.
Perfusion 2010 Jul;25;249-52; discussion 253-4 2010 Jul
A young woman with pulmonary hemorrhage and hypoxic respiratory failure.
Chest 2010 Feb;137;484-7 2010 Feb
Silicone injection causing acute pneumonitis: a case series.
Lung 2009 Aug;187;241-4 2009 Aug
Silicone pulmonary embolism: report of 10 cases and review of the literature.
Journal of computer assisted tomography 2009;33;233-7 2009
Case report and literature review: acute pneumonitis and alveolar hemorrhage after subcutaneous injection of liquid silicone.
Annals of clinical and laboratory science 2008;38;380-5 2008
Silicone embolism syndrome: a case report, review of the literature, and comparison with fat embolism syndrome.
Chest 2005 Jun;127;2276-81 2005 Jun
Clinicopathologic review of pulmonary silicone embolism with special emphasis on the resultant histologic diversity in the lung--a review of five cases.
Yonsei medical journal 2002 Apr;43;152-9 2002 Apr
Acute pneumonitis after subcutaneous injections of silicone for augmentation mammaplasty.
Chest 1994 Oct;106;1152-5 1994 Oct

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