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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Oxygen (dioxygen, O2)

4

XI.e Respiratory acidosis - Hypercapnia

1
Last update : 31/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Oxygen-induced hypercapnia in COPD: myths and facts.
Critical care (London, England) 2012 Oct 29;16;323 2012 Oct 29
Unrecognized severe postoperative hypercapnia: a case of apneic oxygenation.
Mayo Clinic proceedings 1998 Jan;73;51-4 1998 Jan
Severe hypercapnia after low-flow oxygen therapy in patients with neuromuscular disease and diaphragmatic dysfunction.
Mayo Clinic proceedings 1995 Apr;70;327-30 1995 Apr

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