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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Oxygen (dioxygen, O2)

4

XV.f Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

2
Last update : 30/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Diffuse alveolar damage in a young cat.
The Journal of veterinary medical science 2011 Oct;73;1347-9 2011 Oct
Postoperative acute respiratory distress syndrome. A complication of amiodarone associated with 100 percent oxygen ventilation.
Chest 1992 Sep;102;980-1 1992 Sep
Diffuse alveolar damage--the role of oxygen, shock, and related factors. A review.
The American journal of pathology 1976 Oct;85;209-28 1976 Oct
Pulmonary hyaline membrane: sites of formation in adult lungs after assisted respiration and inhalation of oxygen.
The Journal of pathology and bacteriology 1968 Apr;95;481-8 1968 Apr
Case records of the Massachusetts General Hospital. Case 7-1967.
The New England journal of medicine 1967 Feb 16;276;401-11 1967 Feb 16

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