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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sunitinib

2

XII.a Left or biventricular dysfunction/failure

3
Last update : 22/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Sorafenib
2

Publications

Cardiotoxicity Monitoring in Patients Treated with Tyrosine Kinase Inhibitors.
The oncologist 2019 Jul;24;e600-e602 2019 Jul
Lung toxicity in a patient treated with sunitinib.
The European respiratory journal 2012 Nov;40;1300-3 2012 Nov
Incidence and risk of congestive heart failure in patients with renal and nonrenal cell carcinoma treated with sunitinib.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011 Sep 01;29;3450-6 2011 Sep 01
Targeted therapies: Risk of heart failure with sunitinib.
Nature reviews. Clinical oncology 2011 Aug 16;8;569 2011 Aug 16
Management of cardiac adverse events occurring with sunitinib treatment.
Anticancer research 2009 May;29;1627-9 2009 May
Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate.
Annals of oncology : official journal of the European Society for Medical Oncology 2008 Sep;19;1613-8 2008 Sep
Acute cardiac failure after sunitinib.
Annals of oncology : official journal of the European Society for Medical Oncology 2008 Mar;19;597-9 2008 Mar
Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor.
Cancer 2008 Jun;112;2500-8 2008 Jun
Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib.
Lancet (London, England) 2007 Dec 15;370;2011-9 2007 Dec 15

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