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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Dronedarone
2
XII.a
Left or biventricular dysfunction/failure
2
Last update :
14/04/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amiodarone
Statins
Publications
Effects of dronedarone started rapidly after amiodarone discontinuation.
Drug safety evaluation of dronedarone in atrial fibrillation.
Worsening heart failure in the setting of dronedarone initiation.
Increased mortality after dronedarone therapy for severe heart failure.