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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Dronedarone

2

XII.a Left or biventricular dysfunction/failure

2
Last update : 14/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amiodarone
5
Statins
4

Publications

Effects of dronedarone started rapidly after amiodarone discontinuation.
Clinical cardiology 2013 Feb;36;88-95 2013 Feb
Drug safety evaluation of dronedarone in atrial fibrillation.
Expert opinion on drug safety 2012 Nov;11;1023-45 2012 Nov
Worsening heart failure in the setting of dronedarone initiation.
The Annals of pharmacotherapy 2010 Sep;44;1496-500 2010 Sep
Increased mortality after dronedarone therapy for severe heart failure.
The New England journal of medicine 2008 Jun 19;358;2678-87 2008 Jun 19

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