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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Topiramate

1

XI.d Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

1
Last update : 03/03/2014
 
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Diagnosing DIRD
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Drug and radiation history
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Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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Publications

Severe non-anion gap metabolic acidosis induced by topiramate: a case report.
The Journal of emergency medicine 2010 May;38;494-6 2010 May
Hyperchloremic, normal anion-gap, metabolic acidosis due to topiramate.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2008 Aug 01;65;1430-4 2008 Aug 01
Migraine and topiramate induced dyspnea.
Headache 2007;47;1453-5 2007

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